Can excessive Vitamin C cause iron overload in thalassemia major patients?

Can excessive Vitamin C cause iron overload in thalassemia major patients?

Thalassemia major is usually identified during childhood and typically requires monthly blood transfusions. One function of Vitamin C is to enhance the absorption of iron. However, excess iron can increase oxidative stress in the body and damage organs. Studies show that antioxidant levels decrease due to high iron levels, which is why thalassemia patients require antioxidants like Vitamin C and Vitamin E. For thalassemia patients, excessive Vitamin C alongside a high-iron diet can be harmful. In general, patients are advised to follow a low-iron diet while taking antioxidants such as Vitamin C to protect the body from internal damage.